N. Osaka leads the head-to-head 3-2 since 2018 against E. Mertens, over 5 matches.
| Surface | E. Mertens | N. Osaka |
|---|---|---|
| Grass | 0 | 2 |
| Hard | 2 | 1 |
| Date | Winner | Score | Event |
|---|---|---|---|
| June 23, 2026 | N. Osaka | 2 - 0 | Bad Homburg · 1/8-finals · grass |
| Aug. 9, 2024 | E. Mertens | 2 - 0 | Toronto · 1/16-finals · hard |
| June 11, 2024 | N. Osaka | 2 - 0 | WTA Hertogenbosch · 1/16-finals · grass |
| March 11, 2024 | E. Mertens | 2 - 0 | WTA Indian Wells · 1/16-finals · hard |
| Sept. 21, 2019 | N. Osaka | 2 - 0 | Osaka · Semi-finals · hard |