N. Djokovic leads the head-to-head 7-1 since 2018 against S. Tsitsipas, over 8 matches.
By surface
| Surface | N. Djokovic | S. Tsitsipas |
| Grass | 1 | 0 |
| Clay | 2 | 0 |
| Hard | 4 | 1 |
Match history
| Date | Winner | Score | Event |
| July 1, 2026 | N. Djokovic | 3 - 0 | Wimbledon · 1/32-finals · grass |
| Aug. 1, 2024 | N. Djokovic | 2 - 0 | Olympic Games · Quarter-finals · clay |
| Jan. 29, 2023 | N. Djokovic | 3 - 0 | Australian Open · Final · hard |
| Nov. 14, 2022 | N. Djokovic | 2 - 0 | Finals - Turin · hard |
| Nov. 5, 2022 | N. Djokovic | 2 - 1 | Paris · Semi-finals · hard |
| Oct. 9, 2022 | N. Djokovic | 2 - 0 | Astana · Final · hard |
| May 15, 2022 | N. Djokovic | 2 - 0 | Rome · Final · clay |
| Oct. 11, 2019 | S. Tsitsipas | 2 - 1 | Shanghai · Quarter-finals · hard |