J. Pegula leads the head-to-head 3-2 since 2018 against M. Keys, over 5 matches.
| Surface | J. Pegula | M. Keys |
|---|---|---|
| Grass | 1 | 0 |
| Hard | 2 | 2 |
| Date | Winner | Score | Event |
|---|---|---|---|
| June 19, 2026 | J. Pegula | 2 - 0 | Berlin · Quarter-finals · grass |
| Jan. 26, 2026 | J. Pegula | 2 - 0 | WTA Australian Open · 1/8-finals · hard |
| Jan. 11, 2025 | M. Keys | 2 - 1 | Adelaide · Final · hard |
| Sept. 4, 2023 | M. Keys | 2 - 0 | WTA US Open · 1/8-finals · hard |
| Oct. 14, 2022 | J. Pegula | 2 - 0 | San Diego · Quarter-finals · hard |